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Cancer Treatment Potential Discovered in Gene Repair Mechanism
ϳԹ researchers have identified a two-pronged therapeutic approach that shows great potential for weakening and then defeating cancer cells. The team’s complex mix of genetic and biochemical experiments unearthed a way to increase the presence of a tumor-suppressing protein which, i...
ϳԹ/University Hospitals AIDS Clinical Trials Unit Launches Outreach to Enlist More Women in Clinical Trials
The ϳԹ/University Hospitals (UH) AIDS Clinical Trials Unit has a new initiative to reach out to women in Northeast Ohio regarding the critical need for them to participate in HIV-related clinical trials. The initiative, titled “You can make a difference” will include co...
ϳԹ Scientists Find Key to Vitamin A Metabolism
Researchers at ϳԹ School of Medicine have uncovered the mechanism that enables the enzyme Lecithin: retinol acyltransferase (LRAT) to store vitamin A — a process that is indispensable for vision. Their findings appeared in the Nov. 10 edition of the online journal, Natur...
ϳԹ to Lead $27.3 Million Federal Grant for Sudden Unexpected Death in Epilepsy (SUDEP)
ϳԹ is one of two universities in the country selected to lead a $27.3 million international effort to identify the causes of a mysterious and deadly phenomenon that strikes people with epilepsy without warning. For the past several years, federal health officials have explored way...
Peptide Shows Great Promise for Treating Spinal Cord Injury
ϳԹ scientists have developed a new chemical compound that shows extraordinary promise in restoring function lost to spinal cord injury. The compound, which the researchers dubbed intracellular sigma peptide (ISP), allowed paralyzed muscles to activate in more than 80 percent of the...
Researchers Characterize a Protein Mutation that Alters Tissue Development in Males Before Birth
ϳԹ researchers have identified a protein mutation that alters specific gender-related tissue in males before birth and can contribute to the development of cancer as well as other less life-threatening challenges. The discovery marks the latest in a series of findings related to t...
ϳԹ Malaria Expert Named One of 100 Leading Global Thinkers for 2014
ϳԹ malaria specialist Brian T. Grimberg, PhD, is among Foreign Policy magazine’s 100 Leading Global Thinkers of 2014 being honored this evening in Washington, DC. Grimberg of the Center for Global Health and Diseases at ϳԹ School of Medicine will recei...
Laboratory Breakthrough Offers Promise for Spinal Cord Injury Patients to Breathe on Their Own Again
ϳԹ researchers have developed a procedure that restores function to muscles involved in the control of breathing – even when they have been paralyzed for more than a year. The breakthrough offers hope that one day patients with severe spinal cord injuries will be able to breathe ag...
Partnership Pays: Collaboration Among ϳԹ, Cuyahoga County, and YMCA of Greater Cleveland Catalyzes More Than $13 Million in Public Health Grants
The Prevention Research Center for Healthy Neighborhoods (PRCHN) at ϳԹ School of Medicine is a key player in nearly $13.32 million in federal grants awarded to improve community health in Northeast Ohio. The Centers for Disease Control and Prevention (CDC) renewed the P...
Delivering a One-Two Punch: New Drug Combination Shows Promise as Powerful Treatment for Breast Cancer
The uncontrolled growth of cancer cells arises from their ability to hijack the cell’s normal growth program and checkpoints. Usually after therapy, a second cancer-signaling pathway will open after the primary one shuts down — creating an ingenious escape route for the cancer cell to survive. The a...