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Accounting for Racial Inequity in Clinical Trials: Dr. Jackson T. Wright Jr. Honored for Reducing Cardiovascular Disease among African Americans
When Jackson T. Wright Jr. MD, PhD, began practicing medicine in the 1980’s, physicians knew that the risks of high blood pressure were greater in African Americans compared to Caucasians. But what was not known was the dramatic difference in effective prevention and treatment strategies between the...
Protein Movement of Hair Bundles in the Inner Ear May Preserve Hearing for Life
Hearing is made possible when hair bundles protruding from the tops of hair cells capture the energy of sound waves, converting them into electrical signals that stimulate the auditory nerve to the brain. These hair bundles are made up of individual hair-like projections, or stereocilia, which sway ...
ϳԹ receives $2 million for smoking cessation research
A ϳԹ School of Medicine team received $2 million from the Patient-Centered Outcomes Research Institute (PCORI) to study a combination approach to help patients stop smoking, particularly those who are socially and economically disadvantaged. The project involves partners...
Biomarker may predict which HER2-negative breast cancer patients will benefit from targeted therapy
A multicenter team led by ϳԹ has demonstrated that brief exposure to a targeted therapy can tell doctors which HER2-negative patients will respond — and which should switch to another kind of treatment. If confirmed in clinical trials, the discovery would provide physicians inval...
ϳԹ scientists discover long-sought genetic mechanism for cancer progression
Genetics researchers from ϳԹ School of Medicine have identified a novel long non-coding RNA (lncRNA), dubbed DACOR1, that has the potential to stymie the growth of tumor cells in the second-most deadly form of cancer in the U.S. — colorectal cancer. The researchers found that thi...
ϳԹ receives $2.3 million federal grant to fund nutritious food access study in Cleveland and Columbus
The National Institutes of Health (NIH) has awarded $2.3 million to ϳԹ to lead a collaborative study of how changes in food options affect residents’ nutritional choices and health over time. Called the Future of Food in Your Neighborhood Study (dubbed foodNEST), the three-year stu...
High blood sugar of diabetes can cause immune system malfunction, leading to more infection and slower wound healing
ϳԹ scientists may have uncovered a molecular mechanism that sets into motion dangerous infection in the feet and hands often occurring with uncontrolled diabetes. It appears that high blood sugar unleashes destructive molecules that interfere with the body’s natural infection-contr...
Key protein drives ‘power plants’ that fuel cells in heart and other key systems in the body
ϳԹ scientists have discovered that a protein called Kruppel-like Factor 4 (KLF4) controls mitochondria — the “power plants” in cells that catalyze energy production. Specifically, they determined KLF4’s pivotal role through its absence — that is, the mitochondria malfunc...
Novel algorithm identifies DNA copy-number landscapes in African American colon cancers
An algorithm dubbed ENVE could be the Google for genetic aberrations — and it comes from ϳԹ. Remember the World Wide Web before the famed search engine? The web offered extraordinary amounts of information, but no consistently reliable way to secure relevant results. Cancer resea...
ϳԹ to lead multi-institutional ‘big data’ project
ϳԹ is one of three institutions nationwide to win federal ‘big data’ grants focused on developing ways to ensure the integrity and comparability of the reams of information the U.S. health care system collects every day. If successful, the work could create enormous new ...