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ºÚÁϳԹÏÍø School of Medicine Scientists Develop Therapeutic Protein, Protect Nerve Cells from Huntington’s Disease
A new scientific study reveals one way to stop proteins from triggering an energy failure inside nerve cells during Huntington’s disease. Huntington’s disease is an inherited genetic disorder caused by mutations in the gene that encodes huntingtin protein. Approximately 30,000 Americans have mutant ...
ºÚÁϳԹÏÍø Researcher Awarded Drexel Prize in Translational Medicine
Jonathan Karn, PhD, Reinberger Professor of Molecular Biology and chairman of the Department of Molecular Biology and Microbiology at ºÚÁϳԹÏÍø School of Medicine, and director of the Case Center for AIDS Research, has been awarded the 2016 Drexel Prize in Translational Medicin...
ºÚÁϳԹÏÍø Researcher Outlines Road Map for Addressing Ethical Concerns Tied to Research on Combination Human-Animal Embryos
Insoo Hyun, PhD, associate professor of bioethics at the School of Medicine of ºÚÁϳԹÏÍø, has proposed a framework for addressing ethical questions surrounding potentially revolutionary research on part-human, part-animal embryos, which can be produced when human stem cells are...
ºÚÁϳԹÏÍø Researchers Receive Major NIH Renewal Grant to Build on Progress in Understanding Crohn's Disease
Fabio Cominelli, MD, PhD, a professor in the departments of Medicine and Pathology at ºÚÁϳԹÏÍø School of Medicine and Director of Case’s Digestive Health Research Institute, has received a five-year renewal program project grant totaling $9.7 million from the National Institut...
ºÚÁϳԹÏÍø Scientists Uncover Common Cell Signaling Pathway Awry in Some Types of Autism
Brain cells grow faster in children with some forms of autism due to distinct changes in core cell signaling patterns, according to research from the laboratory of Anthony Wynshaw-Boris, MD, PhD, chair of the department of genetics and genome sciences at ºÚÁϳԹÏÍø School of Med...
ºÚÁϳԹÏÍø Researchers Identify New Drug Cocktail to Protect Mouse Retinas, Potentially Avoiding Blindness
In microseconds, every light ray that enters the eye triggers an explosion of coordinated cellular events. Entering light rays focus on a light-sensitive tissue at the back of the eye called the retina while nearby nerve cells convert the rays into cascades of signals that travel through the optic n...
Fused Genes Found in Esophageal Cancer Cells Offer New Clues on Disease Mechanisms
Despite years of research, cellular mechanisms contributing to cancers like esophageal adenocarcinoma have remained elusive. What has puzzled researchers was how genes in the healthy cells lining the esophagus turned the normal cells into malignant ones. Now, researchers from ºÚÁϳԹÏÍø Un...
ºÚÁϳԹÏÍø Researchers Identify Protein that Delays Type 1 Diabetes Onset in New Mouse Model
A new study reveals a counterintuitive cellular strategy that may protect insulin-producing cells from destruction during type 1 diabetes. Type 1 diabetes is an autoimmune disease that accounts for about 5% of the nearly 30 million diagnosed cases of diabetes in the United States, according to the C...
Fluoride Consumption Linked to Diabetes Using Mathematical Models
Water fluoridation prevents dental cavities, which are a costly public health concern. But despite the benefits supplemental water fluoridation remains a controversial subject. Some indicate it may cause long term health problems, but studies reporting side effects have been minimal or inconclusive....
Researchers Restore Drug Sensitivity in Breast Cancer Tumors
A team of ºÚÁϳԹÏÍø School of Medicine cancer researchers has uncovered one way certain tumors resist vital medication. In the study published in Oncotarget, the researchers studied tumor biopsies collected from breast cancer patients before and after treatment with the go-to ...