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Keith R. McCrae, MD
ProfessorDepartment of Molecular MedicineCleveland Clinic Lerner College of Medicine of ºÚÁϳԹÏÍøMemberDevelopmental Therapeutics ProgramCase Comprehensive Cancer CenterDirectorClassical HematologyCleveland Clinic Taussig Cancer InstituteDirectorPhysician-Scientist DevelopmentLerner Research Institute, Cleveland ClinicEmail: mccraek@ccf.org
Phone: 216.445.8185
My focus is in vascular function in health and disease; inflammation and thrombosis, antiphospholipid antibodies, and miRNA.
Brian McDermott, PhD
Associate ProfessorDepartment of OtolaryngologySchool of MedicineAssociate ProfessorDepartment of Genetics and Genome SciencesSchool of MedicineEmail: brian.m.mcdermott@case.edu
Phone: 216.844.6036
My research involves neurobiology of the auditory hair cell: mechanotransduction, synaptic transmission, and development. I also research Zebrafish models of deafness.
Thomas M. McIntyre, PhD
ProfessorDepartment of Molecular MedicineSchool of MedicineMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: mcintyt@ccf.org
Phone: 216.444.1048
I investigate lipid signaling molecules that control intracellular functions in human inflammation. I also research enzymes that make and inactivate lipid signaling molecules, and their roles in human disease.
Timothy J. Mead, PhD
Assistant ProfessorDepartment of PediatricsSchool of MedicineStaff ScientistDepartment of PediatricsUniversity Hospitals Cleveland Medical CenterAssistant ProfessorDepartment of Genetics and Genome SciencesSchool of MedicineEmail: tjm192@case.edu
Phone: 216.368.2350
Our research centers on how changes in the extracellular matrix results in dysfunctional heart development and resulting congenital heart defects. We utilize preclinical mouse models of congenital heart disease, cell culture, genomics, biochemistry, and proteomics to understand the molecular mechanisms underlying these diseases towards the development of therapeutic approaches. Our current major research focus is on the novel concept of inhibiting a protease that remodels fibrillin microfibrils in the aorta to identify a therapeutic for Marfan syndrome.
Jason A. Mears, PhD
Graduate Program DirectorDepartment of PharmacologySchool of MedicineProfessorDepartment of PharmacologySchool of MedicineAssociate DirectorTraining and EducationCase Comprehensive Cancer CenterMemberMolecular Oncology ProgramCase Comprehensive Cancer CenterEmail: jam348@case.edu
Phone: 216.368.3348
My research focuses on structural and functional studies to reveal the impact of mitochondrial dynamics on cell health and proliferation in human diseases, including cancer, neurodegeneration and cardiomyopathy. My areas include cryo-electron microscopy, biochemistry, computational biology, and cancer stem cell models.
Lin Mei, MD, PhD
Allen C. Holmes Professor of Neurological DiseasesDepartment of NeurologyEmail: lin.mei@case.edu
Phone: 216.368.4928
I research synapse assembly and function, psychiatric disorders including autism and schizophrenia, neurological disorders such as ALS, muscular dystrophy, and myasthenia gravis.
William C. Merrick, PhD
ProfessorDepartment of BiochemistrySchool of MedicineEmail: wcm2@case.edu
Phone: 216.368.3578
My research focuses on mechanism and regulation of eukaryotic protein biosynthesis.
Sam Mesiano, PhD
William H. Weir, MD, Professor of Reproductive BiologyDepartment of Reproductive BiologySchool of MedicineProfessorDepartment of Physiology and BiophysicsSchool of MedicineEmail: Sam.Mesiano@Case.edu
I study hormonal interactions and signaling mechanisms that control the process and timing of human birth.
Tyler E. Miller, MD, PhD
Assistant ProfessorDepartment of PathologySchool of MedicineMemberImmune Oncology ProgramCase Comprehensive Cancer CenterEmail: tymiller@case.edu
Phone: 216.286.2807
The goal of our lab is to create effective immunotherapies for brain tumor patients. Our research utilizes advanced single-cell genomics, spatial transcriptomics, and human organoid models to understand immunosuppressive myeloid cells in brain tumors and how to target these to make CAR-T therapies and immune checkpoint therapies more effective. Learn more at tymillerlab.org
Helen Miranda, PhD
Associate ProfessorDepartment of Genetics and Genome SciencesSchool of MedicineAssistant ProfessorDepartment of NeurologySchool of MedicineEmail: helen.miranda@case.edu
Phone: 216.368.8811
My area of investigation include contributions of motor neuron, skeletal muscles, astrocytes and cortical neurons to neuromuscular and neurodegenerative disorders using patient derived stem cells.