We are interested in understanding the fundamental mechanism of innate immunity and its impact on adaptive immunity, inflammation and cancer. We are currently employing multifaceted approaches and mouse disease models to uncover the novel immunostimulatory or immunosuppressive mechanisms of cGAS-STING pathway in antitumor immunity and autoimmunity. The knowledge gained from these studies will be applied to guide the development of new immunotherapies for cancer and inflammatory diseases.
Research Information
Research Interests
The overarching goal of our lab is to gain key molecular insights into innate immune regulations in tumor microenvironment (TME), with a goal of harnessing innate immunity to remodel the TME for better cancer immunotherapy. Currently we mainly focus on understanding the molecular regulation of cGAS-STING signaling in cancer cell and in T cells, and how they shape antitumor immune response.