Neural Engineering Center Seminars
Presenter: Nrupen Pakalapati
Advisor: Dominique Durand
Abstract: Current methods for detecting epileptic activity often require numerous invasive electrodes, posing technical challenges. This study explored a novel approach: using a single recording electrode within white matter tracts like the corpus callosum (CC) or fimbria to detect widespread epileptic activity. Our in vitro and in vivo experiments consistently showed that these single white matter electrodes could effectively identify epileptic activity originating from broad cortical and hippocampal regions in both hemispheres. We also observed the clear propagation of epileptic activity between hemispheres through these white matter tracts, and importantly, an increase in the Root Mean Square (RMS) values from white matter recordings directly correlated with increased epileptic activity. These findings suggest that recording from a single white matter electrode is a promising, less invasive, and more efficient method for real-time epilepsy monitoring and could enable advanced closed-loop management strategies.