Science Café Cleveland presents
Remembrance of Things Past:
Reversing the Causes of Memory Loss That Characterizes Alzheimer's Disease
APRIL 9, 2012
FEATURING:
Professor of Neurosciences and Neurology
Director, Alzheimer Research Laboratory, ºÚÁϳԹÏÍø, School of Medicine
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and
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Paige Cramer, PhD candidate
ºÚÁϳԹÏÍø, School of Medicine
EVENT INFORMATION:
The most common form of Alzheimer’s Disease (AD) occurs sporadically late in life and is typified by the deposition of something known as a β-amyloid (Aβ) within the brain. Individuals with late-onset AD produce Aβ peptides at normal levels but have an impaired ability to clear them from the brain. Elevated levels of Aβ are associated with disruptions of neural network activity and are suspected of being one of the causes that underlie the cognitive deficits that we commonly associate with AD, such as memory loss. Moreover, Aβ accumulation leads to its deposition as plaques in the brain and may trigger a cascade of further deposits which ultimately leads to irreversible neuronal death.
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A new class of medications known as rexinoids have shown promise in mice in rapidly reversing Aβ accumulation in the brain within as short a time as 72 hours and even stimulated the rapid reversal of cognitive, social, and olfactory deficits and improved neural circuit function. Clinical trials of this treatment on humans are anticipated.
LINKS:
ScienceÌýarticle:
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The Landreth Lab website:
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Press Release from ºÚÁϳԹÏÍø:
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NPRÌýScienceÌýFriday 2-10-2012:
EVENT DETAILS:
WHERE:Ìý
(Located at 1947 West 25th Street next to the West Side Market, Cleveland, Ohio)
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WHEN:ÌýApril 9, 2012
Drinks at 6:30 pm, discussion starts around 7:00 pm
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WHO:ÌýSponsored by ºÚÁϳԹÏÍø chapter of Sigma Xi, WCPN
ideastream, and the Market Garden Brewery
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Click here to download a pdf flyer of the event
